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Knee Arthritis - a review on exercise, weight loss, and physical therapy!

Dr. J | a board certified Internist and Nephrologist practicing in the DC/Metropolitan area with over 30 years of clinical experience

We did a detailed blog and topic overview on knee pain/arthritis in the past – let's switch gears a bit. This post will focus on exercise and physical therapy as potential therapeutic options for knee osteoarthritis (referred to as OA).

To recap – knee osteoarthritis is commonly referred to as a “wear and tear” injury that occurs over time as our cartilage which typically serves as a sort of shock absorber between the bones of the knee joint erodes. Subsequent bone on bone pressure leads to inflammation. Data now shows a much more complex ecosystem leading to inflammation than simple “wear and tear” that is a mix of inflammatory mediators, biomechanical factors such as shear stress or ligament damage, and protease involvement. Regardless the cause – once knee osteoarthritis is diagnosed clinically and on imaging – there are limited tools to help alleviate symptoms. 


Unfortunately – an estimated fourteen million people in the United States have symptomatic knee OA, with more than half of those being younger than 65 years of age. United States data from 2007 to 2008 report 7 percent of adults over 25 as having symptomatic knee OA – which is just a massive. Sadly - the disease burden of knee osteoarthritis is accelerating in prevalence with some study data estimating the lifetime risk of developing symptomatic knee OA at approximately 40 percent in men and 47 percent in women - with the highest risk in individuals with a body mass index over 30. 

This infographic from the US Centers for Disease Control highlights the growing disease burden of osteoarthritis -

The potential therapies for knee osteoarthritis include anti-inflammatory medications or herbals supplements (Hello Organic Arthritis!), injections, or eventual surgical joint replacement. However, a mainstay of management often gets overlooked - simple exercise/therapy/weight loss regimens to strengthen structures around the joint and alleviate further pressure/force on the joint. 


A Cochrane review that included 54 total trials - 19 of which were considered as "low risk of bias" - concluded there is moderate-to high-quality evidence suggesting that land-based exercise improves knee pain and function. Also, among people with knee osteoarthritis, land-based therapeutic exercise provides short-term benefit that is sustained for at least 2-6 months after cessation of formal treatment exercise regimens.


Another large review article  noted the magnitude of effect with formal exercise/therapy is comparable to that reported for oral nonsteroidal antiinflammatory drugs (NSAIDs) and much better than Acetaminophen Arthritis (Tylenol Arthritis).


An article in the Journal of the American Medical Association on the IDEA trial randomized 454 overweight and obese adults with knee OA into one of three groups: diet plus exercise, diet alone, or exercise alone. Participants in the diet plus exercise group had the highest percentage of weight lost (11.4 percent of body weight) and improvement in pain after 18 months, achieving a decrease in pain scores of approximately 50 percent, with 38 percent of patients reporting no or little pain at the end of the trial. Moreover, a dose-response relationship between the extent of percentage change in body weight and improvement in joint symptoms has been demonstrated, with more robust effects achieved when at least a 10 percent reduction in body weight is attained. Meta-analysis reviews may hint that a  reasonable initial target  is a 5 to 10 percent weight reduction within a six-month period with the initial goals being updated periodically and individually for each individual.

So now we have some compelling data that exercise, especially when coupled with potential weight loss for individuals with higher body mass index (>30) is a treatment option with potentially sustained durable response over time -  the big question is what is the preferred exercise regimen? The problem - at present, there is no strong evidence on the best prescription of exercise modalities and dosage (ie, intensity, duration, and frequency).


Generally - an exercise regimen/prescription is a highly personalized item which ideally is generated at the hands of seasoned and certified physical therapists. Having said that - some general instructions for those on self dedicated regimens do make sense.


  • Combination of low-impact aerobic fitness training (eg, walking, cycling, rowing, and deep-water running) and lower-limb strengthening exercises, which addresses the full spectrum of impairments in most patients with knee OA. Exercise choice should be tailored based on an individuals mobility, specific impairments (eg, strength, range of motion, aerobic fitness, and balance), and preferences. Exercises involving high impact on the joints such as running or jumping are usually discouraged in order to avoid further joint damage, especially in cases of more advanced OA, although research evidence demonstrating an association between running and progression of knee OA is scarce


  • For those patients who already run or jog for exercise and develop mild symptoms of OA but wish to continue running -  consider a load management approach with a focus on rest days, running surfaces, distance and speed, and footwear, as well as building up muscle strength. Stretching or flexibility exercises, particularly of the hamstrings to avoid or minimize flexion contracture of the knee, can also be part of the exercise program to increase knee range of motion


  • Aquatic exercise also have a potential clinically relevant effect on knee pain, function, and stiffness. Per this Cochrane Review the benefits may be small when compared with non-treatment controls. Still aquatic training may be particularly useful for patients with severe pain and/or poor physical function due to its better tolerance and lower potential to cause adverse events (less shear force on the joints)



Dedicated physical therapy and muscle strengthening can also add potential additional benefits. This graphic below from Veritas Health highlights the potential benefit if knee exercises on the actual knee joint itself.

Now we always advocate an evaluation by trained and experienced licensed physical therapists particularly those who specialize on the knee joint/lower extremities; however, here are some great resources on exercises that can typically be done at home to strengthen muscles around the joint. (Click on the link to open the webpages):







Thanks for taking time out to join us on this journey! We sincerely hope Organic Arthritis assists you in staying active and on your path to healthy and meaningful living!

By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience 20 Nov, 2022
We all know the importance of staying active and exercising. It is advice we have heard many times as we navigate the twists and turns known as life. Often it is easier said than done especially for those with arthropathy and joint pains. However, we must fight the battle and remain as mobile and dynamic as possible. Because data shows that our quality of life, overall health, and even life expectancy itself are greatly impacted by our patterns of activity.
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience 08 Aug, 2022
Osteoarthritis is commonly referred to as the “wear and tear” degenerative joint disease. It typically results from the gradual loss of cartilage - the tough connective tissue that is within/between joints. In a way too simple analogy of this complex mechanism - this cartilage serves as essentially a shock absorber preventing direct shear force or “bone on bone” pressure. Once the shock absorber is weakened/gone – trauma will slowly lead to inflammation and erosion of the joint (PAIN!). This leads to a pretty straightforward question - is there a way to repair or at the least slow down the decline of cartilage? Enter Glucosamine - which is an amino sugar and precursor in the synthesis of glycosylated lipids and proteins. It is a natural compound that exists in our cartilage. 
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience 31 Jan, 2022
Osteoarthritis is one of the most common medical conditions in the world and is commonly referred to as “wear and tear” degenerative joint disease. It typically results from the gradual loss of cartilage within/between joints. This cartilage serves as a type of shock absorber preventing direct shear force and “bone on bone” pressure. Once the shock-absorber is gone it will slowly lead to inflammation and erosion of the joint. US Centers for Disease Control data estimate approx 60 million people with doctor diagnosed arthritis – and remember many people live with joint aches/pain without seeing a physician or getting a formal diagnosis of OA. Sadly the symptoms of OA simply do not stop at the joint. The Arthritis Foundation notes that individuals with OA are almost three times more likely to develop cardiovascular disease (CVD) or heart failure than those without OA. Also, people with osteoarthritis experience as much as 30 percent more falls and have a 20 percent greater risk of fracture than those without OA. These links are especially strong when arthritis is in certain weight bearing/balance joints, such as the knee/back/hip. It makes sense – pain/weakness especially in our stabilizing joints such as knees/hips/spine will limit mobility and lead to risk factors such as weight gain, cardiovascular disease, diabetes coupled with stability issues. These patients would have difficulty following American Heart Association recommendation s that recommend increased physical activity and note that becoming more active can help lower blood pressure and also boost levels of good cholesterol. Without regular physical activity, the body slowly loses its strength, stamina and ability to function well - People who are physically active live about 7 years longer than those who are not active and are obese (American Heart Association). Studies have shown that adults who are inactive/minimally active more than 4 hours a day had a 46% increased risk of death from any cause and an 80% increased risk of death from cardiovascular disease! So now let us focus on some of the clinical presentations of Osteoarthritis (OA). In general there is a marked variability of disease expression. Although most patients present with joint pain and functional limitations, the age of disease onset, sequence of joint involvement, and disease progression vary from person to person. OA ranges from an asymptomatic, incidental finding on clinical or radiologic examination to a progressive disabling disorder eventually culminating in "joint failure" with impaired mobility and quality of life. The primary symptoms of osteoarthritis (OA) are joint pain, stiffness, and motor restriction. Symptoms usually present in just one or a few joints in a middle-aged or older person. Other manifestations in patients with OA include sequelae such as muscle weakness, poor balance, and associated conditions such as fibromyalgia (a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues).
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience 24 Nov, 2021
Osteoarthritis is oftentimes characterized in simple terms - typically referred to as a “wear and tear” injury to a specific joint. This usually involves the weight bearing joints of the body such as the lower back (lumbar spine), the hips, or the knees but can also include common repetitive use joints such as the fingers/toes and also the ankle (especially if historical trauma/injury is noted). In actuality - osteoarthritis is a complex system with many mediators that can affect degradation of joints/cartilage. There are multiple mechanisms that can help trigger erosive joint disease - including several metabolic triggers. In this excellent review by Wang/Hunter et a l from Osteoarthritis and Cartilage - they have an interesting info graphic highlighting potential metabolic contributors to OA (shared below).
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience 20 Sep, 2021
Falls are a major issue especially in our elderly population and falls are the leading cause of injury, both fatal and nonfatal, among older adults in the United States . I can not even count the number of lives that were significantly (and often times permanently) changed after a fall through my decades of practice as a Nephrologist and Internist.
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience 05 Sep, 2021
Cultures around the world, originally in eastern philosophy, have utilized mind body movement exercises for generations for various potential mental and physical benefits. These practices have increased in popularity and scope and are now truly global disciplines such as yoga and tai chi . Yoga likely was founded in Indi a and entails discipline in physical, mental, and spiritual realms with originally strong followings in the hindu and buddhist doctrines. It has morphed from being tied to a single country and also bypassed religious connotations. The term "yoga" in the Western world often denotes a modern form of hatha yoga and posture-based physical fitness, stress-relief, and relaxation techniques sometimes accompanied with breathing exercises The focus of yoga in this modern sense is to blend posture based positions/poses to help facilitate exercise for the body and potentially mind. There are many different disciplines/variations of Yoga with significant fluctuations in their physical demands. Many researchers/physicians attempt to quantify the strenuousness of exercises by their energy cost of exercise commonly measured in metabolic equivalent of task (MET). Less than 3 METs counts as light exercise; 3 to 6 METs is moderate; 6 or over is vigorous. American College of Sports Medicine and American Heart Association guidelines count periods of at least 10 minutes of moderate MET level activity towards their recommended daily amounts of exercise. For healthy adults aged 18 to 65, the guidelines recommend moderate exercise for 30 minutes five days a week, or vigorous aerobic exercis e for 20 minutes three days a week. Treated as a form of exercise, a complete yoga session with asanas (body posture) and pranayama (focusing on breath) discipline provides 3.3 ± 1.6 METs which would be classified as an average/moderate workout in strenuousness. There have been several hundred published articles/scientific trials on Yoga and its potential health benefits. Let us focus on some of the data for arthropathy. In one randomized control trial by Deepeshwar et al - Sixty-six individual diagnosed with with knee osteoarthritis (ages between 30 and 75 yo) were randomized into two groups. One group would then participate in yoga for 1 week at a yoga center ( n = 31) and then a control ( n = 35) group who did not participate in any yoga activities. Multiple functional tests were performed on day 1 and then at day 7 - including the Falls Efficacy Scale (FES), Handgrip Strength test (left hand LHGS and right hand RHGS), Timed Up and Go Test (TUG), Sit-to-Stand (STS), and right & left extension and flexion. Results indicated a significant reduction in TUG ( p < 0.001), Right ( p < 0.001), and Left Flexion ( p < 0.001) whereas significant improvements in LHGS ( p < 0.01), and right extension ( p < 0.05) & left extension ( p < 0.001) from baseline was found in the yoga group. This would suggest improved muscular strength, flexibility, and functional mobility in the yoga group. This was a small study that also was completed over a short time frame (1 week) but did show marked functional improvements. Let us look at more data via a large review by Haaz et a l . Researchers combed through peer-reviewed clinical trials (published from 1980-2010) that used yoga as an intervention for arthritis patients and reported quantitative findings. Eleven studies were identified, including four randomized control trials and four non randomized trials. The trials reviewed data is below in the table.
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialists with over 30 years of clinical experience 22 Aug, 2021
Let us review an interesting study from the Harvard medical system published in the American Journal of Clinical Nutritio n and also Osteoarthritis and Cartilage Journal by Xu et all dealing with the potential impacts of dietary intake patterns and progression of Knee osteoarthritis. There is an age old saying - "You are what you eat" and there has been past data on certain foods/nutrients linked with outcome effects on knee arthritis such as (click the links below for reference articles): Soft drink consumption (potential increased risk of OA progression) Milk consumption (potential decreased risk of OA progression particularly in women) Dietary fat intake (potential increased risk of OA progression) Strawberrie s (potential decreased risk of OA progression particularly in obese adults) Fiber intake (potential decreased risk of OA progression) We also know of many herbs that have varying arthritis control data (some very convincing) and our own Organic Arthritis Herbal Supplement is composed of strong data driven herbs for arthropathy control. There have been past study links between a general Mediterranean diet having a relative lower risk of and improved overall symptom control of knee OA. This study focuses more on overall diet classes and effects on osteoarthritis. This study compares two diet classes based on the Scree test via individual diet questionnaires: Western Diet - composed of high intakes of red and/or processed meats, refined grains, and french fries Prudent Diet - composed of high intakes of vegetables, fruit, fish, whole grains, and legumes
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialists with over 30 years of clinical experience 06 Aug, 2021
Arthritis is one of the most common medical conditions diagnosed in the United States and world-wide. CDC US data notes there are approximately 60 million individuals battling arthropathy with that estimate rapidly growing to an estimated 78 million (26%) US adults aged 18 years or older projected to have doctor-diagnosed arthritis by 2040 .
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialists with over 30 years of clinical experience 12 Jul, 2021
Many of us have heard of the medical term INSOMNIA . It refers to a medical condition in which individuals have difficulty falling, staying, or getting back to sleep. There can be short term sleep issues lasting nights or weeks, termed acute insomnia , or long term sleep disturbances ranging months to years, termed chronic insomnia . This can lead to a multitude of general health ramifications. The first question - how much sleep is recommended daily? According to United States Centers for Disease control recommendations - adults should generally have 7 or more hours of sleep nightly to help ensure optimal functional status. This CDC table below helps show National Sleep Foundation and American Academy of Sleep Medicine recommendations:
By Dr. J | a board certified Internist and Nephrologist practicing in the DC/Metropolitan area with over 30 years of clinical experience 11 Jun, 2021
There is a strong chance all of us are aware of or have used non-steroidal anti-inflammatory drugs (commonly referred to as NSAIDs) in our lifetimes. There also is a good chance many have been told by their medical providers to avoid using NSAIDs especially long term given the risk factors for particular those with chronic kidney disease, congestive heart failure, resistant hypertension, gastritis/stomach ulcers, or even those with electrolyte concerns such as hyperkalemia (high potassium) or hyponatremia (low sodium). Despite these risks – NSAIDs are simply the most recommended/prescribed anti-inflammatory medications in the world today. This class of medications includes such commonplace names as (click underlined links below for more info): 1) Advil 2) Aleve 3) Ibuprofen 4) Motrin 5) Naprosyn/Naproxen 6) Diclofenac/Voltaren 7) Celebrex/Celecoxib 8) Mobic (Meloxicam) 9) Indomethacin/Indocin Though often times effective for inflammatory control - there are several noted risks to NSAIDs particularly in those with chronic kidney disease. NSAIDs provide their analgesic, anti-inflammatory, and antipyretic actions through inhibition of cyclooxygenase (COX) enzymes – which convert arichidonic acid (released from cell membranes) to prostaglandins and thromboxanes. This graphic in the American Journal of Kidney Disease highlights this COX cascade pathway affects:
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