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NSAIDs use in Chronic Kidney Disease - a growing problem!

Dr. J | a board certified Internist and Nephrologist practicing in the DC/Metropolitan area with over 30 years of clinical experience

There is a strong chance all of us are aware of or have used non-steroidal anti-inflammatory drugs (commonly referred to as NSAIDs) in our lifetimes. There also is a good chance many have been told by their medical providers to avoid using NSAIDs especially long term given the risk factors for particular those with chronic kidney disease, congestive heart failure, resistant hypertension, gastritis/stomach ulcers, or even those with electrolyte concerns such as hyperkalemia (high potassium) or hyponatremia (low sodium). 


Despite these risks – NSAIDs are simply the most recommended/prescribed anti-inflammatory medications in the world today. This class of medications includes such commonplace names as (click underlined links below for more info):


1)    Advil

2)    Aleve

3)    Ibuprofen

4)    Motrin

5)    Naprosyn/Naproxen

6)    Diclofenac/Voltaren

7)    Celebrex/Celecoxib

8)    Mobic (Meloxicam)

9)    Indomethacin/Indocin


Though often times effective for inflammatory control - there are several noted risks to NSAIDs particularly in those with chronic kidney disease. NSAIDs provide their analgesic, anti-inflammatory, and antipyretic actions through inhibition of cyclooxygenase (COX) enzymes – which convert arichidonic acid (released from cell membranes) to prostaglandins and thromboxanes. This graphic in the American Journal of Kidney Disease highlights this COX cascade pathway affects: 



Via the inhibition of the COX1/2 cascades - NSAIDs can potentially lead to decreased perfusion of blood flow entering our kidneys filtration system which can negatively affect kidney function along with other potential adverse effects such as sodium retention (swelling + blood pressure elevation), Congestive heart failure exacerbations, elevated potassium levels (referred to as hyperkalemia), and decreased sodium levels (referred to as hyponatremia) in the blood stream.


These adverse risks the largest societies on kidney care guidelines recommend to limit use of NSAIDs in the chronic kidney disease patient populations.


1)    Kidney Disease Improving Global Outcomes (KDIGO) – guidelines from Kidney International - recommend to avoid prolonged use of NSAIDS in stage 3 chronic kidney disease and to completely avoid use in stages 4 and 5 CKD


2)    KDOQI US-guidelines by the National Kidney Foundation also recommend to avoid prolonged use of NSAIDS in stage 3 chronic kidney disease and to completely avoid use in stages 4 and 5 CKD


3)    Treatment of pain in patients with renal insufficiency: the World Health Organization three-step ladder approach also recommend to avoid NSAIDS entirely in stage 3/4/5 CKD


So now we know that NSAIDs in general should be cautioned/avoided in those with Chronic Kidney Disease – but there remains an issue – many individuals with CKD continue to regularly take NSAIDs. The reason is that there are few western alternatives for arthritis/pain control. Tylenol Arthritis (Acetaminophen) has weak data overall with several studies and analysis of trial data noting it has an effect only slightly better than placebo and much weaker than NSAIDs. Opioid data is even worse – with studies noting the tolerability of opioids is low and efficacy is not clinically relevant in controlled studies for osteoarthritis pain. The side effect profile of opioids is worse and many have died from these medications as this CDC graph shows:

In this cohort study in the Journal of Internal Medicine via the Center for Kidney Research, Education, and Hope (CURE-CKD) registry, more than 2.6 million adults and children had chronic kidney disease or were evaluated. Unfortunately – NSAID usage remains fairly regular and actually rising over the most recently evaluated years in the CKD population - look at this graphic below:

We had to dig deep and look for alternative options for our patients in need of solutions. Several herbs have been used in holistic medicine for generations for inflammation control such as curcumin, capsaicin extracts, ginger, willow bark, cloves, fenugreek, or nigella sativa. There is a multitude of bench data as well as clinical trial data (including several randomized control trials) for several of these herbs/extracts. We began looking into herbal/holistic substances and we  parsed basic science/bench as well as clinical research databases. Our ingredients have shown to suppress the inflammatory cascade with the caveat of no known issues with kidney function / Sodium retention / Blood Pressure elevation / stomach lining erosion that plague chronic NSAID use. In 2014 after some testing and adjustments - we solidified a powder based regimen and would at times suggest patients seeking alternative/additional relief try it. We did not commercially sell it but would just suggest individuals obtain and try the ingredients on their own.

 

The response was tremendous and more often than not this became their go to relief agent. The only consistent suggestion (and complaint) was the taste of the powders and the need for a tablet to ease delivery/use. We adjusted the extract ratios/concentrations and were able to manufacture (made in the USA at an FDA registered and GMP certified facility) a coated (should be tasteless) tablet also scored to decrease size to help ease use. The feedback and reviews have been phenomenal (click here to see our Amazon reviews). We sincerely hope Organic Arthritis assists you in staying active and on your path to healthy and meaningful living. Thanks for taking time out to join me on this journey!

By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience November 20, 2022
We all know the importance of staying active and exercising. It is advice we have heard many times as we navigate the twists and turns known as life. Often it is easier said than done especially for those with arthropathy and joint pains. However, we must fight the battle and remain as mobile and dynamic as possible. Because data shows that our quality of life, overall health, and even life expectancy itself are greatly impacted by our patterns of activity.
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience August 8, 2022
Osteoarthritis is commonly referred to as the “wear and tear” degenerative joint disease. It typically results from the gradual loss of cartilage - the tough connective tissue that is within/between joints. In a way too simple analogy of this complex mechanism - this cartilage serves as essentially a shock absorber preventing direct shear force or “bone on bone” pressure. Once the shock absorber is weakened/gone – trauma will slowly lead to inflammation and erosion of the joint (PAIN!). This leads to a pretty straightforward question - is there a way to repair or at the least slow down the decline of cartilage? Enter Glucosamine - which is an amino sugar and precursor in the synthesis of glycosylated lipids and proteins. It is a natural compound that exists in our cartilage. 
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience January 31, 2022
Osteoarthritis is one of the most common medical conditions in the world and is commonly referred to as “wear and tear” degenerative joint disease. It typically results from the gradual loss of cartilage within/between joints. This cartilage serves as a type of shock absorber preventing direct shear force and “bone on bone” pressure. Once the shock-absorber is gone it will slowly lead to inflammation and erosion of the joint. US Centers for Disease Control data estimate approx 60 million people with doctor diagnosed arthritis – and remember many people live with joint aches/pain without seeing a physician or getting a formal diagnosis of OA. Sadly the symptoms of OA simply do not stop at the joint. The Arthritis Foundation notes that individuals with OA are almost three times more likely to develop cardiovascular disease (CVD) or heart failure than those without OA. Also, people with osteoarthritis experience as much as 30 percent more falls and have a 20 percent greater risk of fracture than those without OA. These links are especially strong when arthritis is in certain weight bearing/balance joints, such as the knee/back/hip. It makes sense – pain/weakness especially in our stabilizing joints such as knees/hips/spine will limit mobility and lead to risk factors such as weight gain, cardiovascular disease, diabetes coupled with stability issues. These patients would have difficulty following American Heart Association recommendation s that recommend increased physical activity and note that becoming more active can help lower blood pressure and also boost levels of good cholesterol. Without regular physical activity, the body slowly loses its strength, stamina and ability to function well - People who are physically active live about 7 years longer than those who are not active and are obese (American Heart Association). Studies have shown that adults who are inactive/minimally active more than 4 hours a day had a 46% increased risk of death from any cause and an 80% increased risk of death from cardiovascular disease! So now let us focus on some of the clinical presentations of Osteoarthritis (OA). In general there is a marked variability of disease expression. Although most patients present with joint pain and functional limitations, the age of disease onset, sequence of joint involvement, and disease progression vary from person to person. OA ranges from an asymptomatic, incidental finding on clinical or radiologic examination to a progressive disabling disorder eventually culminating in "joint failure" with impaired mobility and quality of life. The primary symptoms of osteoarthritis (OA) are joint pain, stiffness, and motor restriction. Symptoms usually present in just one or a few joints in a middle-aged or older person. Other manifestations in patients with OA include sequelae such as muscle weakness, poor balance, and associated conditions such as fibromyalgia (a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues).
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience November 24, 2021
Osteoarthritis is oftentimes characterized in simple terms - typically referred to as a “wear and tear” injury to a specific joint. This usually involves the weight bearing joints of the body such as the lower back (lumbar spine), the hips, or the knees but can also include common repetitive use joints such as the fingers/toes and also the ankle (especially if historical trauma/injury is noted). In actuality - osteoarthritis is a complex system with many mediators that can affect degradation of joints/cartilage. There are multiple mechanisms that can help trigger erosive joint disease - including several metabolic triggers. In this excellent review by Wang/Hunter et a l from Osteoarthritis and Cartilage - they have an interesting info graphic highlighting potential metabolic contributors to OA (shared below).
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience September 20, 2021
Falls are a major issue especially in our elderly population and falls are the leading cause of injury, both fatal and nonfatal, among older adults in the United States . I can not even count the number of lives that were significantly (and often times permanently) changed after a fall through my decades of practice as a Nephrologist and Internist.
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialist with over 30 years of clinical experience September 5, 2021
Cultures around the world, originally in eastern philosophy, have utilized mind body movement exercises for generations for various potential mental and physical benefits. These practices have increased in popularity and scope and are now truly global disciplines such as yoga and tai chi . Yoga likely was founded in Indi a and entails discipline in physical, mental, and spiritual realms with originally strong followings in the hindu and buddhist doctrines. It has morphed from being tied to a single country and also bypassed religious connotations. The term "yoga" in the Western world often denotes a modern form of hatha yoga and posture-based physical fitness, stress-relief, and relaxation techniques sometimes accompanied with breathing exercises The focus of yoga in this modern sense is to blend posture based positions/poses to help facilitate exercise for the body and potentially mind. There are many different disciplines/variations of Yoga with significant fluctuations in their physical demands. Many researchers/physicians attempt to quantify the strenuousness of exercises by their energy cost of exercise commonly measured in metabolic equivalent of task (MET). Less than 3 METs counts as light exercise; 3 to 6 METs is moderate; 6 or over is vigorous. American College of Sports Medicine and American Heart Association guidelines count periods of at least 10 minutes of moderate MET level activity towards their recommended daily amounts of exercise. For healthy adults aged 18 to 65, the guidelines recommend moderate exercise for 30 minutes five days a week, or vigorous aerobic exercis e for 20 minutes three days a week. Treated as a form of exercise, a complete yoga session with asanas (body posture) and pranayama (focusing on breath) discipline provides 3.3 ± 1.6 METs which would be classified as an average/moderate workout in strenuousness. There have been several hundred published articles/scientific trials on Yoga and its potential health benefits. Let us focus on some of the data for arthropathy. In one randomized control trial by Deepeshwar et al - Sixty-six individual diagnosed with with knee osteoarthritis (ages between 30 and 75 yo) were randomized into two groups. One group would then participate in yoga for 1 week at a yoga center ( n = 31) and then a control ( n = 35) group who did not participate in any yoga activities. Multiple functional tests were performed on day 1 and then at day 7 - including the Falls Efficacy Scale (FES), Handgrip Strength test (left hand LHGS and right hand RHGS), Timed Up and Go Test (TUG), Sit-to-Stand (STS), and right & left extension and flexion. Results indicated a significant reduction in TUG ( p < 0.001), Right ( p < 0.001), and Left Flexion ( p < 0.001) whereas significant improvements in LHGS ( p < 0.01), and right extension ( p < 0.05) & left extension ( p < 0.001) from baseline was found in the yoga group. This would suggest improved muscular strength, flexibility, and functional mobility in the yoga group. This was a small study that also was completed over a short time frame (1 week) but did show marked functional improvements. Let us look at more data via a large review by Haaz et a l . Researchers combed through peer-reviewed clinical trials (published from 1980-2010) that used yoga as an intervention for arthritis patients and reported quantitative findings. Eleven studies were identified, including four randomized control trials and four non randomized trials. The trials reviewed data is below in the table.
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialists with over 30 years of clinical experience August 22, 2021
Let us review an interesting study from the Harvard medical system published in the American Journal of Clinical Nutritio n and also Osteoarthritis and Cartilage Journal by Xu et all dealing with the potential impacts of dietary intake patterns and progression of Knee osteoarthritis. There is an age old saying - "You are what you eat" and there has been past data on certain foods/nutrients linked with outcome effects on knee arthritis such as (click the links below for reference articles): Soft drink consumption (potential increased risk of OA progression) Milk consumption (potential decreased risk of OA progression particularly in women) Dietary fat intake (potential increased risk of OA progression) Strawberrie s (potential decreased risk of OA progression particularly in obese adults) Fiber intake (potential decreased risk of OA progression) We also know of many herbs that have varying arthritis control data (some very convincing) and our own Organic Arthritis Herbal Supplement is composed of strong data driven herbs for arthropathy control. There have been past study links between a general Mediterranean diet having a relative lower risk of and improved overall symptom control of knee OA. This study focuses more on overall diet classes and effects on osteoarthritis. This study compares two diet classes based on the Scree test via individual diet questionnaires: Western Diet - composed of high intakes of red and/or processed meats, refined grains, and french fries Prudent Diet - composed of high intakes of vegetables, fruit, fish, whole grains, and legumes
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialists with over 30 years of clinical experience August 6, 2021
Arthritis is one of the most common medical conditions diagnosed in the United States and world-wide. CDC US data notes there are approximately 60 million individuals battling arthropathy with that estimate rapidly growing to an estimated 78 million (26%) US adults aged 18 years or older projected to have doctor-diagnosed arthritis by 2040 .
By Dr. J | American Board of Internal Medicine certified Nephrologist and Internal Medicine specialists with over 30 years of clinical experience July 12, 2021
Many of us have heard of the medical term INSOMNIA . It refers to a medical condition in which individuals have difficulty falling, staying, or getting back to sleep. There can be short term sleep issues lasting nights or weeks, termed acute insomnia , or long term sleep disturbances ranging months to years, termed chronic insomnia . This can lead to a multitude of general health ramifications. The first question - how much sleep is recommended daily? According to United States Centers for Disease control recommendations - adults should generally have 7 or more hours of sleep nightly to help ensure optimal functional status. This CDC table below helps show National Sleep Foundation and American Academy of Sleep Medicine recommendations:
Knee Arthritis - a review on exercise, weight loss, and physical therapy!
By Dr. J | a board certified Internist and Nephrologist practicing in the DC/Metropolitan area with over 30 years of clinical experience June 13, 2021
Knee Arthritis - a review on exercise, weight loss, and physical therapy!
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